@article {Lesnicp2639, author = {Evelina Lesnic and Vasile Zlepca}, title = {Risk factors for anti-tuberculosis treatment failure}, volume = {38}, number = {Suppl 55}, elocation-id = {p2639}, year = {2011}, publisher = {European Respiratory Society}, abstract = {The effectiveness of DOTS at new TB cases must achieve 95\% in Moldova is 70\%. The patients with increased risk for failure and relapse are marginalized people.The diagnosis, organization and supervision of the treatment is difficult and the rate of failure is very high. Intrinsic risk factors for treatment failure, those related to the patient, can be under control of the physician, instead extraneous factors, are not related to the disease, but influence the outcome: poverty, ignorance, contact with active TB, they must be covered by the national TB control programs.We estimated risk factors for treatment failure at 96 new TB cases hospitalized in the municipal hospital of Chisinau. Intrinsic factors revealed were: male sex 69 cases (70\%), young age 25-44 yrs, 65 cases (66\%), severe forms: infiltrative TB 75 cases (76\%) and fibrocavernous TB 9 (10\%), disseminated infection 60 cases (61\%) with bilateral extension 71 cases (72\%), pulmonary bleeding 19 cases (20\%), pleurisy 12 (13\%), 2/3 of cases had a coexisting pathology (alcoholics 19 cases, smokers 17, COPD 20 cases, 6 HIV-infected), 3 pregnant women, 8 cases with adverse drug reactions with changing of the therapeutic schedules. The extraneous factors were poverty and bad living conditions 90 (91\%) unemployment 66 (67\%), low educational status 69 (70\%), 46 (47\%) had a familiar contact with a TB patient, 34 (35\%) had MDR strains in the sputum culture. For 77 cases (78\%) the diagnosis was established with a delay more than 3 mnths after the onset of TB. All listed factors associated with the errors in treatment have induced emergence of MDR-TB that contribute to more problems in management of TB control programs.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p2639}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }