%0 Journal Article %A Erika Halasova %A Marian Adamkov %A Tatiana Matakova %A Elena Kavcova %A Eva Rozborilova %A Dusan Dobrota %T Expression of survivin and p53 protein in pulmonary tumours %D 2011 %J European Respiratory Journal %P p1485 %V 38 %N Suppl 55 %X Survivin is a member of the inhibitor of apoptotic gene family, which has been implicated in both the inhibition of apoptosis and mitosis regulation. p53 is one of the tumour suppressor genes; prevents tumour formation through cell cycle blocking and eliminates damaged cells via activation of apoptosis. To investigate the possible regulation of survivin by p 53 we examined the expression of both proteins in 67 patients with diagnosed lung cancer using immohistochemical visualisation. Survivin was predominantly expressed in both nucleus and cytoplasm, whereas p53 was expressed in nucleus. There was negative correlation between survivin and p53 expression. Decreased intensity of expression and less number of positive cells for survivin in small cell lung cancer in comparison to other lung cancer types was detected. There was no significant difference in intensity of expression and in number of positive cells for p53 between small cell and non-small cell lung cancer types.This work was supported by project “Center of excellency for research in personalized therapy (CEVYPET) co-financed from EC sources and European Regional Development Fund. %U