@article {Teixeirap2593, author = {Nelson Teixeira and Teresa Carvalho and Isabel Gomes and Jos{\'e} Agostinho Marques}, title = {Adults without HIV infection hospitalised for tuberculosis {\textendash} Clinical and drug sensitivity profiles}, volume = {38}, number = {Suppl 55}, elocation-id = {p2593}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Background: Tuberculosis (TB) remains a major health problem and an important cause of hospitalisation for severity.Aims: To evaluate clinical and drug sensitivity profiles of patients without HIV infection hospitalised for TB.Methods: A retrospective study of adults admitted for TB to a tertiary hospital between 2007-2010, without HIV infection. Age, gender, clinical presentation,co-morbidities, radiological findings, diagnosis, drug sensitivity, therapy and outcome were evaluated.Results: The study included 207 patients, 18 to 89 years (mean 54,3 years).Of all, 69,6\% had pulmonary TB, 10,1\% pleural TB, 12,6\% disseminated disease and 7,7\% other forms. Co-morbidities were found in 136 patients. Main chest X-ray findings were unilateral (23,2\%) or bilateral (17,9\%) infiltrates, cavitation (14,5\%) and pleural effusion (14,5\%). M. tuberculosis was isolated in bronchial secretions in 125 cases, bronchial lavage in 46, gastric aspirate in 25, bronchoalveolar lavage in 23 and other products in 40. There was sensitivity to all first line TB drugs in 85,2\% cases, mono-resistance in 10,9\%, poly-resistance in 3,3\% and multi-drug resistance in 0,5\% (a extensively resistant case). Streptomycin (12,6\%) and isoniazid (6,0\%) had the highest resistance. Death occurred in 22 patients (10,6\%), 86,4\% had severe co-morbidities. The other patients were transferred to other hospitals (7) or discharged to out-patient TB clinics (178), 99 of them also referred to hospital consultations.Conclusions: In this group of patients co-morbidities were frequent, mortality was relevant and pulmonary TB was predominant as expected. TB drug sensitivity profile was not significantly different from ambulatory patients.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p2593}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }