TY - JOUR T1 - Transitional change of the relationship between clinical efficacy of treatment for pulmonary MAC disease and drug-sensitivity test for MAC isolated JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - 3398 AU - Yoshihiro Kobashi AU - Masaaki Abe AU - Keiji Mouri AU - Yasushi Obase AU - Naoyuki Miyashita AU - Mikio Oka Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/3398.abstract N2 - Objective: We investigated the relaltionship between the clinical efficacy of treamtent for pulmonary MAC disease and drug-sensitivity test for isolated MAC compared 2005-2007 and 2008-2010.Materials and methods: The subjects consisted of 60 patients who satisfied the diagnostic criteria of ATS and received the combiation therapy using RFP, EB, SM and CAM. We divided into the former period (24 patients) and the latter period (36 patients).Results: The average administration dose of CAM has been increased from the former period (517mg/day) to the latter period (800mg/day) between both periods. Sputum conversion rate has been increased frm 63% in the former period to 83% in the latter period. Clinical improvement has been increased from 38% in the former period to 53% in the latter period. The causative microorganisms isolated were M.avium in 35 patients and M.intracellulare in 25. There were no significant differences in the sputum conversion rate, clinical improvement, and drug-sensitivity test between M.avium and M.intracellulare in both periods. The isolated MAC strains showed excellent MICs of CAM and RFP in both periods. Regarding the relationship between clinical efficacy and MICs of RFP, EB, CAM, and SM, there was a good relationship only for CAM in both periods.Conclusions: The good clinical effect has been obtaied with the increase dose of CAM in the latter period. Because there was no significant difference in the result of drug-sensitivity test for isolated MAC in both periods, we speculated that the increase of administration dose of CAM has been influenced the good clinical effect in both periods. ER -