TY - JOUR T1 - Pulmonary hypertension and right ventricular impairment in patients with sarcoidosis JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3727 AU - Nina Karoli AU - Andrey Rebrov Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3727.abstract N2 - There is little date about frequency of pulmonary hypertension (PH) and right ventricular (RV) impairment in patients with sarcoidosis. In this work we examined the prevalence PH in these disorders using noninvasive cardiopulmonary evaluation.33 patients (aged 50,64±2,84) with sarcoidosis have been studied. 8 pts was with R I stage and 26 with RII stage of sarcoidisis. Criteria of exception were the clinical displays heart disease, heavy arterial hypertension. Control group have made 14 normotensive volunteers (aged 47,57±1,86). All patients were studied using realtime, phased array, two-dimensional Doppler echocardiography. The pulmonary artery systolic pressure (SP) was calculated as the sum of the transtricuspid pressure gradient and the right atrial pressure.Results: PH (SP>35 mm Hg) is revealed at 18 patients (52.9%) and 10 pts (30.3%) had SP > 40 mm Hg. Doppler-estimated SP at the patients with sarcoidosis exceeded SP at the healthy persons (p<0.001). RV hypertrophy was present in 84,8% patients (p<0.001 with controls). RV dilation was present in 90% patients with sarcoidosis (p<0.001). Right atrial diameter in patients with sarcoidosis was higher than at the healthy persons (p<0.001). RVwall in patients with sarcoidosis was higher than at the healthy persons (p<0.001). RVdiameterl in patients with sarcoidosis was higher than at the healthy persons (p<0.001).RV diastolic dysfunction we noted in 58.3% pts.We noted a correlation between SP and MRS scale (r=0,52, p<0,01), VC (r=-0,44, p<0,01), FVC (r=-0,46, p<0,01), duration of disease (r=0,46, p<0,01), SaO2 (r=-0,42, p<0,01).Conclusion: Pulmonary hypertension and right ventricular abnormalities is common in patients with sarcoidosis. ER -