%0 Journal Article %A Sergey Avdeev %A Marina Makarova %A Alexander Chuchalin %T Arterial stiffness and endothelial dysfunction in idiopathic pulmonary fibrosis (IPF) %D 2011 %J European Respiratory Journal %P p647 %V 38 %N Suppl 55 %X Background: Fibrotic lung diseases are associated with an increased prevalence of coronary artery disease and cardiovascular complications [Kizer et al., 2004]. Arterial stiffness and endothelial dysfunction are widely accepted as markers of cardiovascular risk.Objectives: The aim of the present study was to assess aortic stiffness and endothelial dysfunction in patients with IPF and to determine the association of these markers with other clinical and functional parameters.Methods: We enrolled 25 IPF patients (age 57±8 yrs; FVC 80±18%; DLCO 38±15%) and 30 normal control subjects (age 52±5 yrs). Assessment of arterial stiffness was performed by use of digital photoplethysmography (Pulse Trace PCA 2, Micro Medical). Change in reflection index of the digital volume pulse in response to salbutamol (ΔRISALB) was used to assess endothelial function.Results: In IPF patients stiffness index (SI) was significantly higher than in normal control subjects: 9.8±3.1 vs 6.9±1.0 m/s (p<0.001). The correlations between SI and sleep time spent with SpO2 < 88% (r=-0.67, p<0.05) and total serum cholesterol level (r=-0.77, p<0.05) were highly significant in IPF patients. ΔRISALB was significantly lower in IPF patients than in control subjects: 2.2±1.2% vs 15.8±9.3% (p=0.01). ΔRISALB was significantly associated with FEV1 (r=-0.57, p<0.05), mean nocturnal SpO2 (r=-0.83, p<0.05) and total cholesterol level (r=-0.71, p<0.05).Conclusions: Arterial stiffness and endothelial dysfunction are significantly impaired in IPF patients. Decreased FEV1 was associated with endothelial dysfunction. Nocturnal hypoxemia and total cholesterol level have an association with both arterial stiffness and endothelial function. %U