TY - JOUR T1 - Acupuncture improves nutritional status and BODE index in patients with chronic obstructive pulmonary disease: A randomized, placebo-controlled trial JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p249 AU - Masao Suzuki AU - Motonari Fukui AU - Tetsuhiro Shiota AU - Kazuo Endo AU - Susumu Sato AU - Kensaku Aihara AU - Masataka Matsumoto AU - Shinko Suzuki AU - Ryo Itotani AU - Manabu Ishitoko AU - Masaya Takemura AU - Yoshikazu Hara AU - Hitoshi Kagioka AU - Masataka Hirabayashi AU - Shigeo Muro AU - Michiaki Mishima Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p249.abstract N2 - Introduction: Prognosis of COPD patients is influenced not only by pulmonary functions but also by nutritional status, exercise capacity and severity of dyspnea. Our previous study (Suzuki M et al. AJRCCM 2010; 181: A5420) showed that acupuncture improved significantly not only Modified Borg Scale at the end of 6-minute walk test (MBS), but also various general conditions of COPD patients including quality of life (SGRQ).Aim and Objective: To determine whether acupuncture had any effects on nutritional status and BODE index of COPD patients in our previous study.Methods: We conducted parallel-group randomized controlled multicentre trials involving 68 COPD patients. The participants were randomly assigned to real (RA, n=34) or placebo acupuncture (PA, n=34). Both group received real or placebo needling once a week for a total of 12 weeks. We evaluated not only change in MBS, as primary endpoint, but changes in pre-albumin, BMI, MRC, 6MWD, and respiratory functions. BODE index was calculated by these data.Results: Six (4 in RA, 2 in PA) withdrew during study. After 12 weeks, RA group showed significant improvements in pre-albumin [22.6 to 25.1mg/dl], BMI [21.2 to 22.6kg/m2], MRC [3.3 to 2.3], 6MWD [373.2 to 436.7m] and%FEV1 [44.5 to 49.2%], as well as MBS [5.5 to 1.9] of primary endpoint. The BODE index decreased significantly in the RA (3.9 to 2.7, p<0.01), but not changed in the PA (3.3 to 3.3, p>0.9; mean difference [95%CI] between groups, -1.2 [-1.8 to -0.63]).Conclusions: This study demonstrated that acupuncture may contribute to improvement of nutritional status and prognosis as well as DOE of the patients with COPD. ER -