RT Journal Article
SR Electronic
T1 Pneumonia and pandemic influenza virus A (H1N1/09). Immediate and remote results
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p4341
VO 38
IS Suppl 55
A1 Alexey Krivonogov
A1 Igor Leshchenko
A1 Zinaida Bobyleva
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p4341.abstract
AB Aim: To assess the clinical presentation, treatment outcomes and long-term results for patients with community acquired pneumonia (CAP) during an Virus A (H1N1)/09 in 2009.Methods: The study includes 250 cases of CAP, which developed in patients with influenza A/H1N1/09 of them men 54.8%. The average age of 45.0 years. Medication consisted of oseltamivir dose to oral 75-150 mg twice daily and cephalosporins III + macrolides II or respiratory fluoro-quinolones. After the end of inpatient treatment based on changes in the lungs according to high resolution CT (HRCT) was administered N-acetylcysteine (NAC) dose to oral 600 mg twice daily (n=41) for 92.0 (95% CI 86.2-97.7) days. Assessments included clinical symptoms, comorbidity, SpO2, laboratory tests, and X-raying.Results: The median period of hospitalization was 15.2 days. The median SpO2 during hospitalization 87.0%, after hospital treatment 94.2%. 76.5% of patients had a 2-side lung. The fatality rate was 10.4%. SYRS was diagnosed in 49.6% of patients (fatality rate was 1.6%), severe sepsis and septic shock in 27.6% of patients (fatality rate was 34.8%). Fatality rate in patients with obesity was 30.0%, with COPD 16.3%. X-ray changes after hospitalization were 82.4% of patients, of whom 56.6% - infiltration of the lung tissue. After treatment with NAC X-ray of the variation persisted in 57% of patients, of whom 7.0% infiltration of lung tissue and 36.0% - the picture “matte”.Conclusion: CAP during an epidemiology outbreak of. Influenza A/H1N1/09 characterized by severe, requires intensive care and long-term observation.