RT Journal Article
SR Electronic
T1 Effect of treatment on exercise endurance tolerance and ventilatory efficiency in patients with pulmonary arterial hypertension (PAH)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2286
VO 38
IS Suppl 55
A1 Dario Martolini
A1 Paolo Onorati
A1 Gabriele Valli
A1 Alessandro Maria Ferrazza
A1 Paolo Marinelli
A1 Mattia Internullo
A1 Liborio Sardo
A1 Cristina Gambardella
A1 Beatrice Pezzuto
A1 Carmine Dario Vizza
A1 Paolo Palange
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2286.abstract
AB Incremental CardioPulmonaryExercise Test (CPET) or 6-Minute Walking Test, (6'MWT) are utilized for the evaluation of Pulmonary Arterial Hypertension (PAH) patients (pts), although the parameters obtained (e.g. peak oxygen uptake -V'O2Peak - and walking distance, respectively) have a different predictive value, depending on outcomes of interest (e.g. prognosis, response to therapy). We evaluated the effect of treatment on principal indexes obtained during CPET, constant work rate test on cycle ergometer (CWR) (e.g. endurance time, TLim), and 6'MWT.Methods: Nine naive PAH pts (age 41±15 SD years; meanPAP 51±13 SD mmHg) underwent, before (PRE) and after (POST) treatment, CPET, CWR (80% max work load at PRE-CPET) and 6'MWT. V'O2, CO2 output (V'CO2), ventilation (V'E), heart rate (HR) and other derived parameters (V'E/V'CO2) were measured breath-by-breath (Quark b2, COSMED, Rome, Italy); PRE- and POST- values at peak and at isotime were compared (paired t-test).Results: During CWR, POST-TLim resulted significantly longer than PRE-TLim (POST-TLim 11'24”± 6'07” vs PRE-TLim 5'38”±3'03”, p<0,02) and POST-V'E/V'CO2 at peak and at isotime was significantly lower compared to PRE-value at peak (p<0,01 and p<0,02 respectively). During CPET, POST- V'O2Peak was not significantly higher than PRE-V'O2Peak (p= 0,06). POST 6'MWT distance resulted significantly higher than PRE-one (p<0,03).Conclusions: The better POST-treatment exercise tolerance in PAH pts seems to be linked to a ventilatory efficiency improvement, and the parameters obtained at CWR and 6'MWT, compared to CPET, appear to be more sensible to the effect of medical treatment.