RT Journal Article
SR Electronic
T1 Interrelationship between clinical symptoms expressiveness and brush-biopsy cell count and proteinases and its inhibitors in sputum at smokers and nonsmokers with COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p4215
VO 38
IS Suppl 55
A1 Ekaterina Bukreeva
A1 Raisa Pleshko
A1 Gulnara Seitova
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p4215.abstract
AB We study relationship between clinical picture and expressiveness of inflammatory changes in bronchi at COPD smokers and nonsmokers.Endobronchial biopsy and brush-biopsy cytological research and definition of elastase and its inhibitors in sputum were conducted at 46 COPD patients. To reveal correlations we used Spearman coefficient. At COPD nonsmokers the expressiveness of cough and dyspnoe has positive correlation with neutrophiles count (R=0.95), dystrophical epithelial cell count (R=0.95) and negative correlation with eosinophiles count (R=-0.95). COPD nonsmokers have positive correlation between elastase activity and goblet cell count (R=0.81) and atrophical epithelial ciliated cell count (R=0.83). It is evidence of influence of elastase on development of atrophy and hypersecretion in COPD exacerbation. COPD smokers have no correlation between cough expressiveness and brush-biopsy cell count, but dyspnoe expressiveness has positive correlation with neutrophiles count (R=0.42), and negative with lymphocytes count (R=-0.70). At COPD smokers the negative correlation was revealed between FEV1 and dystrophical epithelial cell count (R=-0.40), between a2MG and reserved cell count (R=-0.42), positive correlation between a2MG and typical epithelial ciliated cell count (R=0.46), proliferated epithelial ciliated cell (R=0.56). That may be caused by capacity of a2MG to increase count of cell mitoses. Smoking influences on inflammation mechanisms at COPD patients, that is reflected on correlations between brush-biopsy cell count, proteinases and its inhibitors in sputum and clinical symptoms expressiveness.