PT  - JOURNAL ARTICLE
AU  - Wenchi Hsu
AU  - Dirk von Hollen
AU  - Zhen Xu
AU  - Tao Bai
AU  - Kurt Nikander
AU  - Richard Dalby
TI  - Breath-by-breath delivered dose comparison from three anti-static valved holding chambers with facemasks under simulated pediatric breathing conditions
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p4831
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p4831.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p4831.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Facemasks serve as a patient-device interface to facilitate drug delivery from a pressurized metered dose inhaler (pMDI) with an attached valved holding chamber (VHC), and are capable of significantly affecting inhalation drug therapy. A novel horizontal test rig designed for the evaluation of facemask performance under simulated conditions was used to measure delivered dose from ProAir HFA pMDIs (108 μg albuterol sulfate/actuation, Teva Specialty Pharmaceuticals LLC). Three brands of VHC-facemask systems were tested: preproduction OptiChamber Diamond (Diamond) VHCs with preproduction LiteTouch facemasks (Philips Respironics), AeroChamber Plus Z Stat (Z Stat) VHCs with ComfortSeal facemasks (Monaghan Medical Corp.), and Vortex VHCs with Spinner Duck facemasks (PARI GmbH).A face replica of a four-year-old child, with a replaceable aerosol filter in the “mouth”, was connected to a breathing simulator (ASL 5000; IngMar Medical Ltd) to simulate a pediatric breathing pattern (Vt=155 mL, f=25 bpm I:E=2:3). Each VHC-facemask system was naturally positioned against the face replica with a constant applied force supplied by a mass of 1.9 kg. Albuterol sulfate was quantified using HPLC after 1, 2, 4 and 8 “breaths” following pMDI actuation.View this table:Table 1. Mean dose recovered on filter (%, n=3)The delivered dose using the Diamond-LiteTouch system, after 1 breath, was significantly higher than the delivered dose using the Z Stat-ComfortSeal or the Vortex-Spinner Duck system after 8 breaths (p<0.01).