RT Journal Article
SR Electronic
T1 OSAS and oxidative stress before and after CPAP therapy
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3059
VO 38
IS Suppl 55
A1 Marco Brunori
A1 Francesca Serena Pignataro
A1 Roberto Pierro
A1 Giulio Onelli
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3059.abstract
AB Obstructive Sleep Apnea Syndrome is frequently associated with oxidative stress which might contribute to the onset of some of the systemic co-morbidities. Repeated hypoxia/re-oxygenation cycles may cause increase in Reactive Oxygen Species (ROS) with a reduction of Nitric Oxide (NO) availability.This study was undertaken to assess oxidative stress in patients with severe OSAS (Apnea-Hypopnea index > 30/h) by evaluation of brachial artery Flow mediated dilation (FMD), gp91phox and serum levels of nitrite and nitrate (NOx), and to test the hypothesis that Continuous Positive Airway Pressure (CPAP) therapy can reduce oxidative stress.We choose FMD as indirect marker of endothelial NO-mediated reactivity; gp91phox for NADPH oxidase activity and serum levels of NOx, markers of nitric oxide generation.We enrolled 10 patients with severe OSAS. After polysomnography, for evaluation AHI and oxygen desaturation index (ODI), FMD, gp91phox and NOx were measured before and after 90 days of CPAP treatment.None of the patients smoked.The mean AHI and ODI prior to CPAP were respectively 43.3±11.9/h and 35.8±22.3/h, which decreased to 7±5/h and 2.8±1.6/h (p<0.001). The mean BMI was 35,3±5,5 kg/m2 and it didn't change during 90 days of therapy. Gp91phox decreased from 38.2±7.4 to 23.6±5.1 (p<0.001).FMD and NOx were not statistically significant.While confirming the association between OSAS and oxidative stress, we found CPAP therapy managed to reduce gp91phox in patients who adhered to treatment for at least 4 hours daily, for 90 days, although there was no significant change in body weight.CPAP treatment could therefore decrease Oxidative stress in patients with OSAS by correction of apnea and restoring normal oxygenation.