RT Journal Article
SR Electronic
T1 Reliability of ATS/ERS criteria for the diagnosis of idiopathic pulmonary fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p4778
VO 38
IS Suppl 55
A1 Shinichiro Ohshimo
A1 Francesco Bonella
A1 Koichi Tanigawa
A1 Nobuoki Kohno
A1 Josune Guzman
A1 Ulrich Costabel
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p4778.abstract
AB Background: The 2002 ATS/ERS Consensus Classification has been widely accepted as the standard classification for interstitial lung diseases (ILD). However, the diagnostic accuracy of the major/minor criteria in the ATS/ERS Classification for idiopathic pulmonary fibrosis (IPF) is still controversial.Aims and objectives: To evaluate the reliability of the major/minor criteria in the ATS/ERS Classification for IPF.Methods: Patients with ILD admitted to Ruhrlandklinik (Essen, Germany) were retrospectively studied. All patients presenting with an insidious onset and a duration of illness of >3 months were included. Because of the concept that the exclusion of known causes for ILD is not always easy, we also enrolled patients with secondary ILD (dust/drug exposure or CVD-associated). The diagnostic accuracy of the major/minor criteria for IPF was evaluated.Results: A total of 163 patients with suspected ILD were studied. The final diagnoses of the enrolled patients were IPF (n=82), other IIP (n=42) and secondary ILD (n=39). In the univariate analysis, the p-value of the criteria (%VC<80%,%TLC<80%,%DLCO<80%, A-aDO2>=25Torr, PaO2<60Torr, typical findings for IPF in HRCT, BAL lymphocytosis <30% age>50, and bibasilar crackles) for the diagnosis of IPF were 0.04, 0.94, 0.65, 0.08, 0.29, <0.0001, <0.0001, 0.97, and 0.0015, respectively. In the multivariate analysis, the typical findings for IPF on HRCT (p<0.0001) and BAL lymphocytosis <30% (p=0.0001) showed independent diagnostic significance for IPF.Conclusions: Typical findings for IPF in HRCT and BAL lymphocytosis <30% were of diagnostic significance for IPF.