PT - JOURNAL ARTICLE AU - A. Vaneylen AU - S. De Vleeschauwer AU - W. Jungraithmayr AU - S. Wauters AU - S. Willems AU - S. Verleden AU - A. Willems-Widyastuti AU - B. Vanaudenaerde AU - D. Van Raemdonck AU - E. Verbeken AU - G. Verleden TI - A new mouse model of bronchiolitis obliterans syndrome DP - 2011 Sep 01 TA - European Respiratory Journal PG - 225 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/225.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/225.full SO - Eur Respir J2011 Sep 01; 38 AB - Background: Long-term survival after lung transplantation (LTx) is hampered by Bronchiolitis Obliterans Syndrome (BOS), morphologically presented by OB. Since the pathogenesis is still not fully understood and the prognosis remains poor a good animal model is indispensable.Aim: The development of a new model of BOS after LTx.Methods: C57Bl6 mice underwent LTx with BALB/C donor lungs and were sacrificed at 2, 4, 6, 10 and 12 weeks after LTx. Staining with H&E and Sirius Red (not shown) were performed.Results: Histology showed two types of lesions. Type I lesions are characterized by lymphocytic bronch(iol)itis and functional lung parenchyma. These lesions seem to resolve over time. Type II lesions are demonstrated by fibrotic plugs growing into the airway lumen, resembling true BO lesions in humans. The surrounding parenchyma however is not functional.Conclusions: Allograft LTx in mice mimics human histology of BO, optimalisation of this model will open new perspectives to study pathogenesis of chronic rejection after LTx.