PT - JOURNAL ARTICLE AU - Thierry Perez AU - Jean Louis Paillasseur AU - Pierre Regis Burgel AU - Nicolas Roche TI - Determinants of dyspnea in stable COPD patients DP - 2011 Sep 01 TA - European Respiratory Journal PG - p256 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/p256.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/p256.full SO - Eur Respir J2011 Sep 01; 38 AB - Background: Dyspnea is a major symptom in COPD, but its determinants remain poorly understood, with usually moderate correlation with clinical and lung function characteristics.Aim of study: To analyse in a multivariate model the correlates of dyspnea in a large COPD cohort, including both clinical and resting lung function data.Methods: Dyspnea was evaluated by the mMRC scale and the baseline dyspnea index (BDI) in 239 patients from the multicenter French COPD cohort Initiatives BPCO. A logistic ordinal regression (with stepwise ascending and descending analysis) was performed with the following variables: age, sex, BMI, FEV1, FVC, GOLD stage, IC, IC/TLC ratio, anxiety and depression scores (HAD; significant if ≥ 10), number of exacerbations, cardiac failure, history of venous thrombo-embolismResults: For MRC score, the following variables were significant contributors to the model: BMI, FEV1, thrombo-embolic history, exacerbation rate, heart failure, HAD depression score. Estimated r2 of the model was 0,33. For the BDI scale, only HAD depression, FEV1, exacerbation rate and heart failure were significant contributors. Estimated r2 of the model was 0,29.Conclusion: Dyspnea correlates in COPD include FEV1, HAD depression score, exacerbation frequency and heart failure. MRC and BDI were explained by slightly different contributors. Contrary to what could be expected, sex, age, and resting hyperinflation did not contribute significantly to dyspnea intensity.