RT Journal Article
SR Electronic
T1 Aerobic training performed for short time do not decrease pulmonary allergic disease in mice
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3906
VO 38
IS Suppl 55
A1 Ronaldo Aparecido da Silva
A1 Rodolfo de Paula Vieira
A1 Francine Maria de Almeida
A1 Clarice Rosa Olivo
A1 Beatriz Mangueira Saraiva
A1 Milton Arruda Martins
A1 Celso Ricardo Fernandes de Carvalho
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3906.abstract
AB Background: Long term aerobic training (AT) seems to decrease airway inflammation in mice with pulmonary allergic disease.Objective: Investigate the effect of short on AT in a murine model of asthma.Methods: Male Balb/c mice were divided in 4 groups: Control, AT, ovalbumin sensitized (OVA) and OVA+AT. Sensitized groups received OVA i.p. (days 0,14, and 28) and were exposed to inhaled OVA1% (30min/3xweek) after the 21th day. The AT protocol as performed in a treadmill and began in the 28th day and was performed for 7 days (1hr/session, 50% of maximal intensity). Evaluations: In vivo respiratory mechanic (Flexivent), differential cell counting in the BALF, and collagen fibers depositions and smooth muscle thickness airways were evaluated by an image analyzer.Results: Physical capacity was increased just in trained groups (AT and OVA+AT; p<0.01). No change was observed in respiratory mechanic among all groups (p>0.05); however, it was observed an increase in inflammatory cell migration and collagen fibers, and smooth muscle thickness in OVA and OVA+AT groups (p<0.05).Conclusions: Short term aerobic training seems do not decrease features of pulmonary allergic disease in mice.