PT  - JOURNAL ARTICLE
AU  - Oana Claudia Deleanu
AU  - Diana Pocora
AU  - Andra Elena Malaut
AU  - Ana Maria Nebunoiu
AU  - Ion Mirelus-Mazilu
AU  - Florin Dumitru Mihaltan
TI  - Influence of smoking on symptoms, comorbidities and severity in a population with obstructive sleep apnea (OSA) versus control
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p4231
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p4231.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p4231.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Rationale: The association of smoking with OSA is uncertain, even is an association with increased upper airway resistance and predisposition to cardiovascular complications.Method: We analyzed 129 OSA patients (65% active smokers, 35% never smokers) with normal lung function, without diurnal hipercapnia, successfully titrated with autoCPAP in lab and a control group of 17 active smokers with ronchopathy, regarding anthropometrical, functional lung data, OSA symptoms, severity, comorbidities and parameters after titration. We used SPSS (T, Chi, Pearsons tests).Results: For OSA group: 22.5% female, 77.5% male, mean values: age 49.6±11.7, body mass index (BMI) 33.6±7, apnea hipopnea index (AHI) 43.1±25.1; for smokers group: index package year (PY) 21±14.4, Fagerstrom score (FS) 3.6±2.5; for control group: 11.8% female, 88.2% male, age 40±12.1, PY 20.7±13.7, FS 4.9±2.5, BMI 29±5.3.Significant differences: OSA patients are less fatigue (p=0.04), have a poorer lung function (FEV1,p=0.036, FVC,p=0.04) (justified by the effects of smoking), are fatter (p=0.025), with apneas more difficult to correct (p=0.018) related to PY (r=0.251, p=0.01). In control group was no difference in terms of smoking, BMI, neck circumference but was a smaller percentage of tonsillar hypertrophy (p=0.043) and diastolic blood pressure (p=0.002).Conclusions: Smoking appears not to influence symptoms, severity, and comorbidities in OSA patients, except a difficult CPAP correction of apneas. Also, smoking does not seem to contribute to the appearance of OSA and tonsilar hypertrophy (cause of OSA). Studies are needed to thoroughly into the mechanisms by which smoking could influence OSA.