RT Journal Article SR Electronic T1 Is the body mass index a determinant of inflammatory status and quality of life in asthma? JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p4058 VO 38 IS Suppl 55 A1 Raquel Lόpez Reyes A1 Miguel Perpiña Tordera YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p4058.abstract AB Introduction: The aim of our study was to determine the relationship between body mass index (BMI), alveolar nitric oxide (CaNO), and the health status of asthmatics by applying the quality of life questionnaire Sydney-modified (AQLQ-S).Material and methods: We studied 139 asthmatics (GINA) between 15 and 75 yr of age (men 45 and women 94) and several degrees of severity. We measured anthropometric variables, baseline spirometry, and nitric oxide exhaled (eNO) at multiple flows (50, 100, 150, 200 and 250 ml/s). Bronchial nitric oxide flux (JaNO) and CaNO were assessed according to Tsoukias model. All patients completed the AQLQ-S questionnaire. For comparisons between two groups, T-student test was used. The relations between NO parameters and other markers were analyzed with partial correlations adjusted for asthma severity.Results: The mean BMI was 26.46±4.97 kg/m2,CaNO 3.89±4,7 ppb and JaNO 2401±2307 nl/sec.There were no statistically significant differences in values of CaNO and JaNO between obese asthmatic group and non obese. The AQLQ-S scores obtained were (mean ± SD): total score: 5.62±1.08; shortness of breath: 5.73±1.14; mood: 5.21±1.24, social restriction: 5.92±1.25; and concern: 5.69±1.10View this table:Correlations between BMI and AQLQ-S scoresConclusions: Obesity determines deterioration in the quality of life of patients with asthma especially in two dimensions: 1) shortness of breath and 2) social restriction. CaNO and JaNO show no relation to the inflammatory state that involves obesity and have no expression in the health questionnaire score used.