@article {Lόpez Reyesp4058, author = {Raquel Lόpez Reyes and Miguel Perpi{\~n}a Tordera}, title = {Is the body mass index a determinant of inflammatory status and quality of life in asthma?}, volume = {38}, number = {Suppl 55}, elocation-id = {p4058}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Introduction: The aim of our study was to determine the relationship between body mass index (BMI), alveolar nitric oxide (CaNO), and the health status of asthmatics by applying the quality of life questionnaire Sydney-modified (AQLQ-S).Material and methods: We studied 139 asthmatics (GINA) between 15 and 75 yr of age (men 45 and women 94) and several degrees of severity. We measured anthropometric variables, baseline spirometry, and nitric oxide exhaled (eNO) at multiple flows (50, 100, 150, 200 and 250 ml/s). Bronchial nitric oxide flux (JaNO) and CaNO were assessed according to Tsoukias model. All patients completed the AQLQ-S questionnaire. For comparisons between two groups, T-student test was used. The relations between NO parameters and other markers were analyzed with partial correlations adjusted for asthma severity.Results: The mean BMI was 26.46{\textpm}4.97 kg/m2,CaNO 3.89{\textpm}4,7 ppb and JaNO 2401{\textpm}2307 nl/sec.There were no statistically significant differences in values of CaNO and JaNO between obese asthmatic group and non obese. The AQLQ-S scores obtained were (mean {\textpm} SD): total score: 5.62{\textpm}1.08; shortness of breath: 5.73{\textpm}1.14; mood: 5.21{\textpm}1.24, social restriction: 5.92{\textpm}1.25; and concern: 5.69{\textpm}1.10View this table:Correlations between BMI and AQLQ-S scoresConclusions: Obesity determines deterioration in the quality of life of patients with asthma especially in two dimensions: 1) shortness of breath and 2) social restriction. CaNO and JaNO show no relation to the inflammatory state that involves obesity and have no expression in the health questionnaire score used.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p4058}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }