@article {Menonp4798, author = {Balakrishnan Menon and V.K. Vijayan and Vishal Bansal and Brijesh Prajapat}, title = {Effect of pulmonary rehabilitation on gas exchange, muscle cross section area and functional parameters in interstitial lung disease}, volume = {38}, number = {Suppl 55}, elocation-id = {p4798}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Introduction: Pulmonary rehabilitation has an important role in the management of interstitial lung diseses (ILD). This study evaluates effect of pulmonary rehabilitation on gas exchange, muscle cross sectional area and functional parameters in patients of ILD.Aims and objectives: To evaluate 6 minute walk distance (6MWD), Mid Thigh Cross Sectional Area on CT (MTCSACT) and Carbon Monoxide Diffusion Capacity (DLCO) before and after pulmonary rehabilitation in patients of ILD.Methods: Twenty eight patients of ILD were randomly allocated to Control and Test groups. The control group received standard medications for 8 weeks while the test group was given supervised pulmonary rehabilitation along with standard medications for 8 weeks.Results: Mean values of 6MWD changed from 476.50{\textpm}61.97 m to 482.64{\textpm}58.33 m in control group [p=0.369]and from 455.64{\textpm}63.55 m to 509.78{\textpm}69.03 m in test group [p=0.015].Levels of DLCO changed from 11.88{\textpm}4.38 ml/min/mmHg to 11.62{\textpm}4.00 ml/min/mmHg in control group [p=0.399] and from 10.80{\textpm}3.73 ml/min/mmHg to 13.08{\textpm}3.87 ml/min/mmHg [p=0.004] in test group.Mean values of MTCSACT changed from 9311.21{\textpm}1987.21 cm2 to 9271.07{\textpm}1918.42 cm2 in control group [p=0.646] and from 9485.21{\textpm}2083.44 cm2 to 10330.71{\textpm}2137.41 cm2 in test group [p=0.031].The difference of means between control and test groups after pulmonary rehabilitation was significant for DLCO, MTCSACT and 6MWD. Positive correlation was obtained between MTCSACT and 6MWD [r=0.7, p=0.006].Conclusion: Pulmonary rehabilitation causes significant improvement in muscle cross sectional area and functional parameters in ILD patients along with significant improvement in gas exchange.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p4798}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }