TY - JOUR T1 - Peripheral airway obstruction is a predictive sign of early asthma JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p978 AU - Takayuki Miyamoto AU - Hitoshi Kobayashi AU - Atsuko Sato AU - Yu Utsumi AU - Yutaka Nakamura AU - Kohei Yamauchi Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p978.abstract N2 - Introduction: Diagnosis of early asthma is important to introduce early intervention. However, despite of many reports, it has not been established yet.Objective: We performed spirometry and Impulse Oschillometry System (IOS) on early asthmatics and compared the data with those of patients with chronic cough symptom (CC) and acute bronchitis (AB).Methods: Patients who complained of chronic cough, wheeze and dyspnea, and had never been diagnosed as bronchial asthma (BA) before were recruited to the present study. After having their informed consent, we performed spirometry and IOS, and measured bronchial hyperresponsiveness (BHR). After several months, these patients were diagnosed as bronchial asthma, chronic cough including cough variant asthma and acute bronchitis by development of symptoms, hematological analysis and other findings.Results: BHR of BA (Dmin: 1.1±1.4; mean±SEM, n=89) was significantly increased compared to CC (5.2±3.4, n= 32) and AB (6.8±7.6, n=23). FEV1 of BA was not significantly decreased compared to CC. However, both%V50 and%V25 of BA were significantly decreased compared to those of CC (%V50: BA vs CC; 49.7±25.9 vs 70.2±16.4, p<0.05,%V25: BA vs CC; 38.1±25.0 vs 54.1±12.3, p<0.05).%R (5-25) measured by IOS was significantly higher in BA than in CC/AB (BA vs CC/AB; 151±76 vs 52±26).Conclusion: Decreases of%V50 and%V25 and increase of%R (5-25) in IOS which indicated peripheral airway obstruction were detected in early asthmatics not in CC. These results suggested that peripheral airway obstruction may be a useful predictive sign of early asthma, which can be detected by spirometry. ER -