TY - JOUR T1 - Daily physical activity is associated with muscle function, health status and fatigue in COPD JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2159 AU - Wytske A. Altenburg AU - Mathieu H.G. de Greef AU - Linda Bossenbroek AU - Bertine M.J. Flokstra-de Blok AU - Nick H.T. ten Hacken AU - Johan B. Wempe Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2159.abstract N2 - Background: Daily physical activity (DPA) level is an increasingly important clinical outcome in COPD research and management. In contrast to exercise capacity, the association of DPA with muscle function, health status and fatigue, has not been investigated extensively.Aim: To investigate if DPA is associated with muscle function, health status and fatigue in mild to very severe COPD patients.Methods: In a cross-sectional analysis we included 84 COPD patients (49 male, GOLD I (n=5), II (n=25), III (n=32), IV (n=22), mean age 59±11 years, FEV1 46±18% pred) who were entering a pulmonary rehabilitation program. DPA was measured with a pedometer (DigiWalker SW-200), muscle force with a handheld dynamometer and muscle endurance with the chair-stand test and the arm-curl test. Health status was assessed with the Groningen Activity Restriction Scale (GARS), Saint George Respiratory Questionnaire (SGRQ) and RAND-36, and fatigue with the Dutch Exertion and Fatigue Scale (DEFS).Results: Mean DPA was 3302±2098 steps/day. Significant Spearman's correlations (p<.05) were demonstrated with: quadriceps force (r=0.249) and endurance (r=0.311), biceps force (r=0.480) and endurance (r=0.355), GARS (r=-0.531), SGRQ activity scale (r=-0.258), RAND-36 physical functioning domain (r=0.504) and vitality domain (r=0.235), and DEFS (r=-0.356).Conclusion: Low DPA associates with low muscle force and endurance, low physical functioning and high fatigue in mild to very severe COPD patients. Whether these variables contribute to the development of a low DPA level in COPD patients should be investigated in longitudinal studies. ER -