TY - JOUR T1 - Fibroblast growth factor 23 (FGF23) and hypophosphatemia in patients with COPD JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3581 AU - Mohamed Elsammak AU - Adel Attia AU - Moosa Suleman Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3581.abstract N2 - Introduction: Previous studies highlighted the importance of phosphate depletion in COPD patients and the association between correction of hypophosphatemia and improvement in respiratory muscle function. Fibroblast Growth Factor 23 (FGF23) is a recently discovered circulating protein that plays a crucial role in renal phosphate reabsorption and body phosphate regulation. FGF23 has been investigated in several diseases but there is currently no published data about FGF23 in COPD.Aims and objectives: The aim of this study was to evaluate whether FGF23 levels correlate with serum phosphate levels and disease severity in COPD patients.Methods: 70 COPD patients aged 63.0±4.6 years and 34 age and sex matched randomly selected controls were studied. Criteria for diagnosing COPD and assessing severity were according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) guidelines. Serum samples were analyzed for routine tests including calcium, phosphate, renal/lytes, and FGF23 levels were measured by a commercially available Eliza kit.Results: There were no differences in serum calcium and Vitamin D levels in COPD patients and controls (P > 0.05). COPD patients had significantly lower serum phosphate levels compared to controls (P< 0.01). Plasma FGF23 was significantly higher in patients compared to controls: 280 (51-968) versus 140 (21-200) RU/ml (P < 0.001). As expected plasma FGF23 levels correlated negatively with serum phosphate (r = -0.799 & P< 0.001). Furthermore plasma FGF23 correlated negatively with FEV1 (r = -0.352 & P = 0.003)Conclusion: This study illustrates a significant increase in plasma FGF23 levels that may contribute to low phosphate levels and disease severity in COPD patients. ER -