RT Journal Article
SR Electronic
T1 The relationship between placenta histological features and asthma severity and prescribed therapy
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p530
VO 38
IS Suppl 55
A1 Olga Lavrova
A1 Maria Petrova
A1 Maria Vakharlovskaya
A1 Elena Shapovalova
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p530.abstract
AB Background: Asthma (A) is a most frequent pulmonary disease in pregnants (12%). Nevertheless the data on influence of its severity and treatment to the placenta structure are insufficient.The goal: to compare placenta histological features in pregnants with different asthma severity and treatment with the same of healthy females.Materials and methods: Histological study was carried out in 118 females with A and 100 healthy females. 75 of A females were administered ICS, but 24 of them rejected ICS intake.Results: Histological study appeared the decrease of amount of patients with coexistence of placenta structure and terms of gestation in A pregnants with mild and moderate persistent A in comparison with healthy females, but without statistical significance.View this table:Table 1Placenta development coexisted terms of gestation in 72% of pregnants, administered ICS and in only 45,8% of A pregnants, rejected ICS intake (p<0,01). Significant differences of chronic placental insufficiency were seen between pregnants with the mild intermittent A and mild persistent BA, as well as with moderate A (35,38%, 51,22% and 71, 43% resp. (p<0,05)). Within pregnants, administered ICS 70% appeared compensated, 25,93% - sub compensated and 7,07% decompensated placental insufficiency. Within patients, rejected ICS values were 47,14%, 45,71% and 7,15% respectively.Conclusions: Treatment with ICS while pregnancy has greater influence to placenta condition in comparison with A severity.