TY - JOUR T1 - Effects of pantoperazole on pulmonary function tests of chronic obstructive pulmonary disease patients, with and without gastro esophageal reflux JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3994 AU - Farhad Malek AU - Raheb Ghorbani AU - Fatemeh Yaghobi Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3994.abstract N2 - Introduction: Association between gastro esophageal reflux (GERD) and spirometric finding in chronic obstructive pulmonary disease (COPD) is subject of controversy. The aim of this investigation is to determine the effect of proton pump inhibitor (pantoprazole) on spirometric finding of COPD patient.Material & method: In this clinical trial, 60 COPD patients were selected and according to questionnaire divide in two groups: with and without GERD (36 and 24 patient respectively). All patient treated with oral pantoprazole 40 mg daily for eight weeks. Spirometry before and after treatment was done. FEV1/FVC, FEV1, FVC, PEF were measured in two groups.Result: Mean PEF in COPD patients with GERD before (55.4) and after pantoprazol had significant difference (55.4, 61.5 respectively) (p = 0.009) but mean FEV1/FVC, FEV1, FVC in both groups and PEF in patients without GERD had no significant difference.Conclusion: This study showed in COPD patient with GERD, treatment with 40mg pantoprazole daily improve PEF but has no effect on other spirometric parameters. ER -