RT Journal Article
SR Electronic
T1 Mean platelet volume in obstructive sleep apnea patients. Another link to cardiovascular disease?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1741
VO 38
IS Suppl 55
A1 Paschalis Steiropoulos
A1 Evangelia Nena
A1 Panagiota Zikidou
A1 Pavlos Zarogoulidis
A1 Nikolaos Papanas
A1 Konstantinos Archontogeorgis
A1 Theodora Gkioka
A1 Eleni Pitta
A1 Argyrios Tzouvelekis
A1 Stavros Anevlavis
A1 Marios Froudarakis
A1 Demosthenes Bouros
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1741.abstract
AB Pobjective and aims: Various studies have examined the association between Obstructive Sleep Apnea (OSA) and cardiovascular risk. Mean Platelet Volume (MPV) has been evaluated as a potential marker of cardiovascular risk in several lines of patients. The aim of this study was to evaluate MPV in relation to OSA severity, as well as to investigate the associations between MPV and anthropometric characteristics and parameters of breathing function during sleep.Materials and methods: This study included 699 subjects with suspected sleep apnea, who were all evaluated by Epworth Sleepiness Scale (ESS), physical examination and polysomnography. According to Apnea-Hypopnea Index (AHI), patients were divided into 4 groups: Group A (n=156) with AHI<5/h; Group B (n=137) AHI: 5-14.9/h; Group C (n=100) AHI: 15-29.9/h and Group D (n=303) AHI ≥30/h. MPV (blood samples anticoagulated with sodium citrate) was measured in two blood cell counters (Sysmex SF-3000 and Sysmex XE 2100).Results: MPV was significantly higher in group D (mean value 11.7±1.2) than in groups A (9.9±1.2), B (9.9±1.6), and C (10.8±1.8) (p <0.001). In all patients, significant correlations were shown between MPV and AHI (p<0.001), average SpO2 (p<0.001), minimum SpO2 (p<0.001), t<90 (p<0.001), Arousal Index (p<0.001) and ESS (p=0.002), while regression analysis revealed no association between MPV and BMI (p=0.855) or age (p=0.774).Conclusions: MPV is higher in patients with severe OSA and is correlated with various indices of breathing function during sleep, suggesting a role in the pathogenesis of cardiovascular risk in OSA patients.