RT Journal Article
SR Electronic
T1 Factors associated with elevated FeNO in infants with recurrent respiratory symptoms
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3404
VO 38
IS Suppl 55
A1 Anne Kotaniemi-Syrjänen
A1 Pekka Malmberg
A1 Kristiina Malmström
A1 Anna Pelkonen
A1 Mika Mäkelä
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/3404.abstract
AB Fractional concentration of exhaled nitric oxide (FeNO) is a non-invasive biomarker reflecting eosinophilic inflammation in bronchial mucosa. Its role in early childhood respiratory disorders is not clear. 136 infants with recurrent lower respiratory tract symptoms underwent measurement of FeNO, lung function tests, and a methacholine challenge test. The median level of FeNO was 19.3 ppb (interquartile range 12.3-26.9 ppb). Children with increased airway responsiveness to methacholine (i.e. the provocative dose of methacholine causing a 40% fall in maximal expiratory flow at functional residual capacity (PD40 V'max,FRC) ≤0.30 mg) had significantly higher FeNO when compared to those with only mild or no airway responsiveness to methacholine (PD40 V'max,FRC ≥0.91 mg).Elevated FeNO (≥27 ppb, i.e. the highest quartile) was associated with maternal asthma, and increased airway responsiveness, but not with atopy, eosinophilia, or lung function.View this table:Factors associated with elevated FeNO. Results of the multivariate analysisIn conclusion, maternal history of asthma, and increased airway responsiveness are associated with elevated FeNO in symptomatic infants.