TY - JOUR T1 - Abnormalities in spirometry, impulse oscillometry and exhaled nitric oxide in the university freshmen who have outgrown of bronchial asthma JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3284 AU - Shingo Takanashi AU - Akihito Hayashi AU - Takeshi Morimoto AU - Kageaki Taima AU - Junichi Denpoya AU - Yoshihito Tanaka AU - Hisashi Tanaka AU - Ken Okumura Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3284.abstract N2 - Background: Incidence of asthma, particularly in childhood, is rising. Current asthma prevalence is higher in children than in adults, suggesting that children with asthma may outgrow their disease. It has been long believed that the prognosis for asthma occurring in infancy or childhood is good, and that in most patients the symptoms would resolve by the age of puberty. However, little is known about the lung function of outgrown subject. In this study, we recruited the subjects who had outgrown of asthma and performed spirometry, impulse oscillometry and exhaled nitric oxide (eNO) measurement.Method: The freshmen in our university with a history of asthma (group A, n=54) and without a history of asthma (group B, n=63) were recruited. All group A subjects were currently free from symptoms and underwent no treatment. Lung function was estimated by CHEST-HI801 (CHEST, JAPAN). Impulse oscillometry was performed using MostGraph (CHEST, JAPAN). Exhaled NO level was measured by NO analyzer (SIEVERS NOA, USA).Results: FEV1% was significantly lower in group A than in group B (88.6±6.1% vs 91.2±4.6%; p=0.01). The mean levels of%FEV1,%Vdot50 and%Vdot25 were lower in group A than in group B, though not significant. The levels of R5-20 and Fres were significantly higher in group A than in group B (R5-20: 0.81±0.07 cmH2O/L/s vs 0.62±0.05 cmH2O/L/s; p=0.03) (Fres: 7.9±0.4 Hz vs 6.4±0.3 Hz; p<0.01). Also, the level of eNO was significantly higher in group A than in group B (49.7±4.3ppb vs 37.4±2.6ppb; p=0.01).Conclusions: The subjects who had outgrown of asthma still have impaired lung function, a follow-up examination of lung function may be needed. ER -