RT Journal Article
SR Electronic
T1 Biphasic cuirass ventilation decreased the indices of pulmonary circulation in patients with secondary pulmonary hypertension
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2288
VO 38
IS Suppl 55
A1 Yoko Sato
A1 Takuma Asakura
A1 Noriyuki Saeki
A1 Kazutetsu Aoshiba
A1 Toru Kotani
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2288.abstract
AB Introduction: Biphasic cuirass ventilation (BCV) is a non-invasive extrathoracic positive/negative pressure mechanical ventilation. We reported BCV decreased pulmonary artery pressure (PAP) in patients with secondary pulmonary hypertension (PH) due to chronic respiratory failure (CRF). In this study, we investigated the effect of BCV on pulmonary circulation to seek the mechanism of decreasing PAP.Methods: Fifteen steady-state PH caused by CRF patients were included. None were given vasodilator and nor diagnosed dehydration. PH was defined as mean PAP (mPAP) >20mmHg determined by right heart catheterization (RHC). Control mode was applied in combination with negative/positive pressure between -15 and - 25cmH2O/3 and 10cmH2O. BCV was performed 1 hour/day for 2 week not to exhaust the patients. Data from RHC, the serum levels of N-terminal proB-type natriuretic peptide (NT-proBNP) and noradrenalin were obtained before and after the trial of BCV. Patients were interviewed the comfort around BCV. Data were analyzed by the Wilcoxon test p<0.05 was considered statistically significant.Results: mPAP, pulmonary artery occlusion pressure and cardiac index decreased significantly (27.3 to 23.1 mmHg, p=0.004, 13.9 to 9.4 mmHg, p=0.018, and 2.72 to 2.44 l/min/m2, P=0.035, respectively) without the increase in pulmonary vascular resistance index. NT-proBNP significantly decreased (240.6 to 110.4 pg/ml, p=0.025, respectively), but noradrenalin didn't change. Eleven patients (73%) answered comfortable during and after BCV.Conclusions: The results suggest BCV decreases cardiac load in these patients. Further studies are needed to assess the clinical and physiological effects of BCV.