PT  - JOURNAL ARTICLE
AU  - Marie Luce Choukroun
AU  - Hala Feghali-Caron
AU  - Fabienne Marquant
AU  - Sandrine Vautrat
AU  - Fabienne Nacka
AU  - Valeriane Leroy
AU  - Mickael Fayon
TI  - Determinants of lung function in school aged children prematurely born before 32 weeks of gestation
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p4311
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p4311.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p4311.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Rationale: Persistent respiratory sequelae have been reported in children prematurely born. The aim of this work was to find the part of neonatal and childhood determinants of the lung function of school aged children born with a gestational GA< 32 weeks.Methods: All the children born with a GA<32 wks, at the CHU de Bordeaux, between 1997 and 2000 were eligible for the study. Their respiratory outcome was evaluated by a respiratory questionnaire and lung function measurements: spirometry, static lung volumes, exercise bronchial responsiveness test, pulmonary diffusing capacity DLCO. Multivariable analysis was used to evaluate the neonatal and childhood determinants of their lung function at school age. The study was approved by the Hospital Ethical Review Committee.Results: Of the 444 eligible children, 151 (Birth Weight= 1355±379g; GA = 30,1±1,7 wks) were included: Age= 8,6±0,8 yrs, Body Weight= 28,4±6,5 kg, Height= 132±8cm. Bronchopulmonary dysplasia BPD occurred in 36,4% of them. At school age 60% had respiratory symptoms. Lung function abnormalities were found in 53,5% of them: obstructive abnormalities with or without distension in 41%, restrictive or mixed abnormalities in 12.5%. Exercise induced bronchial responsiveness was positive in 41%. DLCO was reduced in 15,5%. Prior BPD was associated with restrictive or mixed abnormalities (OR:6,1, CI 95%:[1,1- 33,9], p=0,04]. Surfactant treatment was protective from lung abnormalities (p=0,03).Conclusion: After premature birth, school aged children remain at risk of impaired lung function especially among those who did not received surfactant. Restrictive lung abnormalities are likely associated with prior BPD.