PT  - JOURNAL ARTICLE
AU  - Carlos Flores Berrios
AU  - Mireya Mendez
AU  - Bernardita Chateau
AU  - Claudia Astudillo
AU  - Hugo Cerda
AU  - Sandra Flores
TI  - Factors associated and attack rate in adenovirus infection among children with chronic respiratory disease
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p1180
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p1180.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p1180.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: Intrahospital adenovirus infections spread easily causing a profound impact in morbidity and mortality associated with outbreaks.Objectives: To identify the attack rate of adenovirus infection in a hospital for children with chronic respiratory diseases (CRD) and to assess the factors associated to the infection.Material and methods: Fifty children with CRD were evaluated between June 2010 and October 2010 at Josefina Martinez Hospital. They were exposed during the Winter Campaign to patients with respiratory infections admitted during that period. “Case” was defined as “Case”. Univariate and multivariate logistic regression models were used to calculate odds ratios and 95% confidence intervals for selected variables: gender, age, tracheostomy and gastrostomy.Results: Twenty four of chronic patients (48%) were younger than 2 years old and nineteen of them (38%) were 2 to 5 years old, 68% of all children have tracheostomy and 50% of them have gastrostomy. The attack rate was 50% in three months. There was no mortality. Risk factor associated with adenovirus infection was age 0 to 23 months old (OR = 11.1, 95% CI 1.12 - 109.6, p = 0.039). There was no association with other variables.Conclusions: It is important to strengthen prevention measures for adenovirus infection, and these should be kept as long as viral shedding is prolonged. Closed hospitals allow a rapid dissemination. Infants are highly vulnerable. Tracheostomy is not associated with increased risk of infection.