PT - JOURNAL ARTICLE AU - Davood Attaran AU - Leila Ghofraniha AU - Elham Ghalenoei AU - Hooshang Rafatpanah AU - Mohamad Khajedaloee AU - Mohamad Towhidi AU - Shahrzad Mohamadzadeh Lari TI - Comparison the frequency of human T-lymphocyte type 1 (HTLV 1) infection in tuberculosis patients with control group without tuberculosis DP - 2011 Sep 01 TA - European Respiratory Journal PG - p3813 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/p3813.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/p3813.full SO - Eur Respir J2011 Sep 01; 38 AB - Introduction: Regarding to recognize the predisposing factors in Tuberculosis infection which is common in Khorasan, Northeastern province of IRAN,this study investigate whether HumanT-lymphocyte type 1 (HTLV 1) as an immunosuppresive factor increase the risk of tuberculosis.Methods and materials: A case –control study was conducted on 278 pulmonary and extrapulmonary tuberculosis during 2007-2010, in city of mashad, capital of khorasan.Tuberculosis has been documented by goldstandard tests like sputumculture, BAL culture or cytology.For detection of HTLV1 antibody, ELISA method and as a confirming test western Blot were performed. Healthy sex and age matched control group were 276 persons.Results: The mean age of tuberculosis patients was 49.6721.36 and 48.3620.74 in controls.In pateints group 114 (41.6%)were male and 160 (58.4%)were female and in controls 123 (44.6)were male and 153 (55.4)were female.Pulmonary tuberculosis was seen in 84.2% in patients. The overall frequency of HTLV1 in TB patients was2.9% and 3.3% in controls.HTLV1 frequency was higher in male cases and increased with ageing.Conclusion: Regarding to this study HTLV 1 infection alone,is not sufficient to increase the risk of tuberculosis.