RT Journal Article
SR Electronic
T1 Tuberculosis is common in ethnic minority patients with chronic kidney disease in United Kingdom, and there is a high level of drug resistance
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2599
VO 38
IS Suppl 55
A1 Paramita Palchaudhuri
A1 Alexandra Riding
A1 Parvin Begum
A1 Marlies Ostermann
A1 Heather Milburn
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2599.abstract
AB Introduction: Chronic kidney disease (CKD) is more common in ethnic minority groups in UK and these patients have a high incidence of TB. We performed a study to characterise ethnicity and resistance patterns of patients with CKD and TB at a large renal unit in London.Methods: 40 CKD patients who developed TB from1994-2010 were analysed retrospectively. Patients were categorised by country of birth and time spent in the UK prior to development of TB, divided into <5 years or >5 years. Resistance patterns were sought as well as HIV status and Vitamin D levels.Results: Ethnicities were: 15 Black-African, 9 Asian, 7 White-British, 6 Black Caribbean, 3 White-Other (including eastern Europe). 27 patients were non-UK born (67.5%). 4 had lived in the UK for < 5 years. Vitamin D levels were performed in 11 patients & were low in 10 (<60nmol/l). 5 patients were HIV positive (3 Black-African and 2 Black-Caribbean). 5 patients (12.5%) had drug resistance (3 Black-African, 1 Black-Caribbean and 1 White-Kosovan) & two of these were HIV positive.Conclusion: Most CKD patients with TB were from ethnic minorities not born in UK. Most had lived in UK for >5 years suggesting TB development was not linked to duration in UK and that CKD is in itself a big enough risk factor. Vitamin D levels were low, as expected in both TB & CKD. Drug resistance (12.5%) was higher in ethnic minorities & HIV+ve patients with CKD, compared to background rate (4.9-6.1%)1. Hence it is important to look out for TB in ethnic minorities with CKD & also for drug resistance.1Number and proportion of tuberculosis cases with drug resistance by country, UK, 2008. www.hpa.org.uk