PT - JOURNAL ARTICLE AU - Lorenza Melosini AU - Federico Lorenzo Dente AU - Elena Bacci AU - Maria Laura Bartoli AU - Antonella Di Franco AU - Federica Novelli AU - Manuela Latorre AU - Vagaggini Barbara AU - Paggiaro Pierluigi TI - Can asthma control test (ACT) replace a global assessment of asthma control according to GINA guidelines? DP - 2011 Sep 01 TA - European Respiratory Journal PG - p3512 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/p3512.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/p3512.full SO - Eur Respir J2011 Sep 01; 38 AB - Background: Asthma Control test (ACT) has been proposed as a surrogate of the assessment of asthma control, but there is controversy if it corresponds to GINA criteria (O'Byrne, ERJ 2010).Aim: To compare GINA assessment of asthma control and ACT scorePatients and methods: We evaluate 68 outpatients (33 in inhaled corticoseroids, ICS, treatment, and 35 ICS-naïve), with mild-to-moderate asthma. Assessment of asthma was based on symptom score (SS), rescue salbutamol (RS), PEF (MA%), pulmonary function, and asthma exacerbations in the last year (GINA guidelines).Results: ACT score significantly correlated with SS (r= 0.49), RS (r= 0.46) and MA% (r= 0.45), not with FEV1. ACT score only partially correlated with GINA categories of well (WC), partly (PC) and uncontrolled (UC) patients.View this table:Contingency table between asthma control level (according to GINA Guidelines, gold standard) and ACT categoriesACT ≥ 20 had high Positive Predictive Value for WC+PC (PPV: 78%), while ACT ≤ 19 had high Negative Predictive Value for UC (NPV: 89%).Conclusion: Cut-of value of ACT has a good accuracy for detecting uncontrolled asthmatics, but not for distinguish well from partly controlled asthmatics. The high correlations with data derived from 2-week diary card recording support ACT as a simple tool for the quantification of symptomatic asthma control.