PT  - JOURNAL ARTICLE
AU  - Abolhasan Halvani
AU  - Maryam Salami
AU  - Mahmood Karimi
TI  - Evaluation of association between OSA and metabolic syndrome, insulin resistance and Hs-CRP
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p2267
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p2267.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p2267.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: Obstructive sleep apnoea (OSA) is an important medical problem that shares many cardiovascular risk factors with metabolic syndrome. This study aimed to evaluate the possible association of OSA severity with metabolic syndrome, Insulin resistance and Hs-CRP.Methods: We evaluated 90 subjects who suspected for OSA (54.92 years). Blood sampling was taken after 12 hours fasting for glucose, insulin, high-density lipoprotein (HDL)-cholesterol, triglycerides, high-sensitivity C-reactive protein (Hs-CRP), and then Overnight polysomnograghy was done. Insulin resistance was assessed by the homeostatic model (HOMA) and metabolic syndrome was evaluated according to The National Cholesterol Education Program's Adult Treatment Panel III report (ATP III), and subjects categorized by OSA severity. We compared three groups: without OSA, mild OSA and moderate to severe OSA.Results: 28 subjects hadn't OSA, 28 and 34 subjects had mild and moderate to severe OSA, respectively. Metabolic score was 3.29±1.21, 3.07±1.27 and 3.59±1.048 in subjects without OSA and mild OSA and moderate to severe OSA, respectively (r=0.13 p=0.22).HOMA index was 56.87±55.84, 106.42±199.68 and 96.23±127.81 (r=0.33 p=0.37) and hs-CRP levels was 1.62±1.8, 2.10±2.24 and 2.36±2.38 ng/ml (r=0.21 p=0.38) order in above three subjects. There was significant association between metabolic score and HOMA index (p=0.01) and also between metabolic score and hs-CRP level (p=0.02)Conclusion: Although Hs-CRP, insulin resistance and metabolic syndrome increase with OSA severity but there was not significant association between apnea hypopnea index and Hs-CRP, insulin resistance and metabolic syndrome.