TY - JOUR T1 - Sleep disordered breathing detected by a new automated ECG analysis in subjects with insomnia JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2203 AU - Thomas Penzel AU - Carmen Garcia AU - Martin Glos AU - Christoph Schoebel AU - Martina Sebert AU - Ingo Fietze Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2203.abstract N2 - Patients with severe complaints of insomnia are sometimes investigated in a sleep laboratory in order to test for other causes of their complaints such as sleep disordered breathing or other sleep disorders.We investigated 64 patients with primary insomnia with cardiorespiratory polysomnography. Sleep stages, arousal and respiratory events were scored according to AASM criteria. ECG was analyzed by a special software (Hypnocore) which can provide a sleep evaluation and a respiratory event score by a new automated analysis. All patients were analyzed in two steps. The second analysis was performed on 54 patients after removing those with bad signal quality, arrhythmias and a total sleep time below 3 hours.The analysis of respiratory events based on ECG in the group of 64 subjects resulted in 52 subjects (48 true negative, 4 false negative) with an RDI0<5/h. 12 subjects (10 true positive, 2 false positive) were scored with an RDI>5/h. Agreement was 0.91. For the second analysis agreement remained the same. Sleep stages in the second analysis were scored surprisingly good: 48.9% (ECG) vs. 48.7% (PSG) for light sleep, 15.7% (ECG) vs. 15.8% (PSG) for slow wave sleep, 14.0% (ECG) vs. 23.4% (PSG) for wake, and 19.9% (ECG) vs. 12.2% (PSG) for REM sleep.Not many respiratory events occur in insomnia patients. These events are detected with a sufficient accuracy using the new ECG based algorithms. Sleep stage analysis based on ECG did show a good ability to distinguish light sleep, slow wave sleep, and wake/REM sleep. To distinguish wake and REM sleep by ECG alone has a lower accuracy due to high sympathetic activity in both states. ER -