RT Journal Article
SR Electronic
T1 Maintenance schedule of subcutaneous allergoid immunotherapy more efficacious than pre-seasonal
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p264
VO 38
IS Suppl 55
A1 Ewa Swiebocka
A1 Grzegorz Siergiejko
A1 Piotr Rapiejko
A1 Zenon Siergiejko
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p264.abstract
AB Pre-seasonal (PS) and maintenance (M) schedules of specific subcutaneous immunotherapy (SCIT) with allergoids are used to treat patients suffering from seasonal allergic rhinitis. Which of them is more profitable? The aim of the study was to compare an efficacy of two schedules of SCIT, PS vs. M.Fifty seven patients included into the study randomly divided into two groups: PS group (n=28) and M group (n=29). Allergovit® 006 – grass pollen (Allergopharma, Germany) was chosen to treat of them. SCIT lasted 3 years. Every year since 1st May-31st August diary cards were fulfilled. Intensity of symptoms (sneezing, nose itching, rhinorrhea, nasal obstruction, eyes itching, lacrymation, eyes reddening, cough and shortness of breath) and concomitant drug consumption were evaluated. Serum total and sIgE were evaluated before and after stopping SCIT. Intensity of a pollination was evaluated every year.Each individual from PS group was injected 30 times and obtained cumulative dose of 86862 SBU, whereas the one from M group - 41injections and 172892 SBU. In 2006 the highest concentration of grass pollen in the air was 197/m3, in 2007 much higher – 475/m3, and in 2008 – 247/m3. The highest intensity of the symptoms in both group were registered in the first season of SCIT (2006). No significant differences between PS and M were found. The intensity of the symptoms decreased in successive years of SCIT, and in M group was more evident. After SCIT the concentration of tIgE and sIgE decreased significantly.Conclusion: Both schedules, PS and M of SCIT with allergoid vaccine are effective in pollinosis patients, but M is more profitable.