TY - JOUR T1 - Respiratory impedance using forced oscillation technique in preschool children with a history of wheezing JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p1116 AU - Claudia Calogero AU - Niccolò Parri AU - Grazia Fenu AU - Peter Sly AU - Barbara Cuomo AU - Massimo Palumbo AU - Enrico Lombardi Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p1116.abstract N2 - Background: This study aimed to assess respiratory impedance using the forced oscillation technique (FOT) in preschool children with a history of wheezing.Methods: FOT respiratory resistance (Rrs) and reactance (Xrs) at 6, 8, 10 Hz, as well as resonant frequency (Fres), were measured in kindergartens. Children were labelled to have a history of wheezing (WZ) if, based on questionnaires, they had had a diagnosis of asthma, or >3 episodes of WZ ever, or WZ during the previous year. All children had no respiratory symptoms or signs at the time of testing. Post-bronchodilator (BD) impedance was assessed 15 min after administration of salbutamol 200 mcg via MDI and a spacer.Results: A total of 165 healthy (H) children (82 female; median age 4.8 yr, range 2.9-6.1) and 64 WZ children (25 female, median age 4.6 yr, range 2.7-6.0) were evaluated. Mean (SD) Rrs, Xrs and Fres are reported in the table. Post-BD changes were not significantly different in the two groups.View this table:Conclusions: Rrs, Xrs and Fres were not significantly different in asymptomatic preschool children with a history of WZ and in controls. Other indices, such as the area under the curve of Xrs, need to be investigated. ER -