PT  - JOURNAL ARTICLE
AU  - Vincent Ninane
AU  - Michela Bezzi
AU  - Christian Geltner
AU  - Xavier Gonzalez
TI  - One year follow-up in the European multicenter study for the treatment of advanced emphysema with bronchial valves
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - 372
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/372.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/372.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - We have reported positive results of a blinded and randomized sham bronchoscopy controlled study that evaluated the IBV® Valve System (Spiration Inc.) in subjects with advanced upper lobe predominant emphysema. After a 3-month evaluation, subjects in the treatment and sham control groups were un-blinded. Then, the control group was allowed to receive valve treatment. In 3 of the 7 centers participating in the study, Ethics approval was obtained for an additional evaluation at approximately 1 year of treatment.Methods: After approximately one year of receiving valves, the evaluations included physical examination, imaging (CT scan to evaluate regional volumetric changes), pulmonary function, questionnaires, exercise and blood gases.Results: All subjects were in stable condition, and satisfied with the outcome. Complete data for paired analysis was available in 25 of 29 subjects that returned for the evaluation. The average time for the evaluations was 13.5±1.3 months. Results are summarized in a table format.View this table:Conclusions: Improvements with IBV Valve treatment are sustained after 1 year. Subjects with advanced emphysema have a fast slope of decline however, palliative treatments with bronchial valves could affect the natural course of this disease.