TY - JOUR T1 - Rhinology findings and their clinical usefulness for closer asthma fenotyping JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4073 AU - Olga Ruzickova-Kirchnerova AU - Vladan Hrabe AU - Ivana Malkusova AU - Milan Terl AU - Petr Panzner AU - Jana Kuntscherova Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4073.abstract N2 - Background: Our previous study conducted on patients with severe persistent asthma documented a strong correlation between eosinophilic inflammation of upper and lower airways.The aim of presented study was to determine whether there are existing differences between the intensity of eosinophilia and/or polyp presentation in upper airways in patients with eosinophilic astma with no clinically significant allergy versus patients with eosinophilic and allergic asthma.Methods: 32 patients with severe persistent asthma were included for evaluation. According to markers of eosinophilia (FeNO, ECP, eo in NM, BALTe, IS and FBC) and allergy (SPT, spec. IgE) we devided asthmatics into three groups: I. eosinophilic and allergic, II. eosinophilic but non-allergic and III. non-eosinophilic. We also focused on presence of perrenial allergy and NSAID intolerance. CT scan of paranasal sinuses, rhinology examination and operation history were included for evaluation of nasal polyps (NP) presentation.Results: Significant correlations were found in eosinophil counts in NM and NP presentation (p=0,0012). Intensity of NP correlated mostly with eosinophilic but non-allergic astma (0,0117). Intensity of eosinophilia in NM and presentation of NP correlated in the group I mostly with mould allergy, in the group II with NSAID intolerance (p<0,05).Conclusion: We found presence of nasal polyps as an negativ prognostic factor in patients with severe asthma - in allergic asthmatics indicates the risk for mould allergy (and possible ABPA or SAFS), in non-allergic astmatics for NSAID intolerance. Previous study data were considered (ERS10L1_6353, ERJ, 2010, 36 Suppl. 54). Supp. by VZ MSM 0021620812 grant. ER -