PT - JOURNAL ARTICLE AU - Dora Bartusek AU - Judit Varga AU - Andras Bikov AU - Tamas Komaromi AU - Gyorgy Losonczy TI - Lung function values as predictors for outcome during non-invasive ventilation in COPD patients DP - 2011 Sep 01 TA - European Respiratory Journal PG - p2096 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/p2096.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/p2096.full SO - Eur Respir J2011 Sep 01; 38 AB - Introduction: The use of non-invasive ventilation (NIV) has markedly increased over the past two decades, and has now become an integral tool in the management of respiratory failure. Although several predictive factors have been suggested for successful NIV treatment, it is still unclear which clinical baseline variable should be used to predict the outcome of the therapy in COPD patients with respiratory failure.Objective: The aim of the study was to determine predictive factors for COPD patients with acute exacerbation receiving NIV.Methods: 38 patients with COPD (mean age: 64.05±11.26, GOLD III-IV) participated in our study. Lung function, blood gas test and blood sampling for CRP and white cell count measurement were performed, as well as smoking history was recorded and APACHE II score was determined at the day of admission to the respiratory care unit. We accepted NIV to be successful, if no additional invasive methods were needed. The clinical data underwent principal component analysis and receiver operating characteristic (ROC) curve was performed to determine the variables for successful NIV treatment. A principal component having an area under the curve (AUC) more than 0.7 was suggested predictive.Results: NIV was successful in 68% of patients. We found principal component capturing the baseline FVC and FEV1 to be the best predictive variable for failure of treatment (AUC=0.9, sensitivity 90%, specificity 80%), however the other parameters were less useful (AUC<0.7).Conclusion: Baseline lung function may be helpful to predict which patient is susceptible to receive additional endotracheal intubation.