RT Journal Article
SR Electronic
T1 Patterns of sensitization in early childhood in farming environment: A French part of the PASTURE/FORALLVENT European birth cohort study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1001
VO 38
IS Suppl 55
A1 Anne Leydier
A1 Vincent Kaulek
A1 Amandine Chauveau
A1 Flora Metzger
A1 Erika von Mutius
A1 Dominique Angèle Vuitton
A1 Jean-Charles Dalphin
A1 Marie-Laure Dalphin
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1001.abstract
AB Background: Cross sectional studies have repeatedly shown that children growing up on a farm had a significantly lower prevalence of atopic sensitization measured by specific IgE (IgEs) in serum but very little is known regarding sensitization tested by skin prick-tests (SPT).Objective: To compare SPT-tested sensitization during the first 4.5 years of life in children born and living on dairy farms (F) and in children of families from the same rural region, but not born and not living on farms (non-F).Methods: 168 children at 1 yr (49% F; 49% boys) and 155 at 4.5 yrs (52% F; 52% boys) were tested by SPT using a battery of 11 (1 yr) and 16 (4.5 yrs) age-and area-adapted allergens. Correspondent serum specific IgEs were measured at both ages.Results: Prevalence of at least one positive SPT was of 8.5% (1 yr), 9.6% (4.5 yrs) in F and 11.6% (1 yr), 19.5% (4.5 yrs) in non-F groups (p=0.05). In the whole population, positive SPT were mainly against food allergens at 1 yr (13/17, 12 for egg antigen) and against aeroallergens at 4.5 yrs (24/26, 15 for seasonal antigens). At 1 yr, 17% of girls had positive SPT, versus 3.5% of boys, compared with 4.5 yrs (10.7% vs 17.5%). No relationship between IgEs-and SPT-tested sensitization was observed at 1 yr. Such a relationship was demonstrated at 4.5 yrs considering all antigens as well as categories (food, seasonal, perennial) but not for each single antigen.Conclusions: The prevalence of positive skin prick tests is significantly lower in children growing up on a dairy farm than in their rural peers. At one year, there is no correlation between SPT-and IgEs-tested sensitizations.