PT  - JOURNAL ARTICLE
AU  - Anne Leydier
AU  - Vincent Kaulek
AU  - Amandine Chauveau
AU  - Flora Metzger
AU  - Erika von Mutius
AU  - Dominique Angèle Vuitton
AU  - Jean-Charles Dalphin
AU  - Marie-Laure Dalphin
TI  - Patterns of sensitization in early childhood in farming environment: A French part of the PASTURE/FORALLVENT European birth cohort study
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p1001
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p1001.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p1001.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: Cross sectional studies have repeatedly shown that children growing up on a farm had a significantly lower prevalence of atopic sensitization measured by specific IgE (IgEs) in serum but very little is known regarding sensitization tested by skin prick-tests (SPT).Objective: To compare SPT-tested sensitization during the first 4.5 years of life in children born and living on dairy farms (F) and in children of families from the same rural region, but not born and not living on farms (non-F).Methods: 168 children at 1 yr (49% F; 49% boys) and 155 at 4.5 yrs (52% F; 52% boys) were tested by SPT using a battery of 11 (1 yr) and 16 (4.5 yrs) age-and area-adapted allergens. Correspondent serum specific IgEs were measured at both ages.Results: Prevalence of at least one positive SPT was of 8.5% (1 yr), 9.6% (4.5 yrs) in F and 11.6% (1 yr), 19.5% (4.5 yrs) in non-F groups (p=0.05). In the whole population, positive SPT were mainly against food allergens at 1 yr (13/17, 12 for egg antigen) and against aeroallergens at 4.5 yrs (24/26, 15 for seasonal antigens). At 1 yr, 17% of girls had positive SPT, versus 3.5% of boys, compared with 4.5 yrs (10.7% vs 17.5%). No relationship between IgEs-and SPT-tested sensitization was observed at 1 yr. Such a relationship was demonstrated at 4.5 yrs considering all antigens as well as categories (food, seasonal, perennial) but not for each single antigen.Conclusions: The prevalence of positive skin prick tests is significantly lower in children growing up on a dairy farm than in their rural peers. At one year, there is no correlation between SPT-and IgEs-tested sensitizations.