RT Journal Article
SR Electronic
T1 Complex outcomes of physical training in COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3647
VO 38
IS Suppl 55
A1 Natalia Meshcheriakova
A1 Andrey Belevsky
A1 Alexander Cherniak
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3647.abstract
AB Background: Exercise and respiratory training is an important part of COPD patient rehabilitation. It improves physical tolerance and lung function, as well as HR QoL.Aim: To assess the exercise and respiratory training impact on systemic effects in COPD patients.Methods: 52 COPD patients, stage III and IV were randomized in 2 groups. Group 1 (63,9±7,5 yr, 34,6±11,5 pack/yr, FEV1 36,4±11,0% pred., FEV1/FVC 39,7±8,2%, CRP 10,7±8,4 mg/l, CES-D 25,9±9,2) received ICS, LABA, tiotropium bromide. Group 2 (64,9±7,8yr, 38,4±5,6 pack/yr, FEV1 33,8±16,4% pred., FEV1/FVC 41,3±10,8%, CRP 14,1±6,7 mg/l, CES-D 26,8±8,5) - the same therapy + exercise and respiratory training: upper and low limb muscles training + Threshold IMT and PEP. CRP, IL-1β, IL6, TNF-α, testosterone, 6MWT, lung function, QoL MOS SF-36, MRC, CES-D-depression questionnaire (1-17 points - not depression, 18 and more - depression) - before and after 4 weeks were evaluated.Results: In group 2 there was the significant improvement in lung function (ΔFEV1: 11,1±8,7%, p<0,05), physical tolerance (Δ6MWT: 85,3±25,7 m, p<0,01), inflammatory markers: ΔCRP: -8,13±7,6 mg/l, p<0,04, ΔIL6: -8,3±4,4 pkg/ml, p<0,05, ΔIL1: -4,1±4,2 pkg/ml, p<0,16, Δtestosterone: 0,79±0,32 nmol/l, p<0,001, QoL parameters (ΔPF: 18,9±8,9%, p<0,001, ΔRP: 21,4±7,8%, p<0,05, ΔMH: 14,0±6,2%, p<0,001). CES-D was -9,4±6,9 points. In the group 1 there was no significant improvement in all parameters. There was no significant changes in TNF-α in both group. Correlation: RV/TLC and CES-D r= -0,70, FEV1/FVC and CES-D r= -0,44, MH and CES-D r= -0,72, SF and CES-D r=0,79.Conclusion: Exercise and respiratory training has an effect on COPD patient systemic effects.