PT  - JOURNAL ARTICLE
AU  - Ludmila Kaptyuk
AU  - Irina Demko
AU  - Angelina Kraposhina
AU  - Natalya Ryazanova
AU  - Olga Ischenko
AU  - Elena Sobko
AU  - Alla Salmina
TI  - Expression of CD38 and its participation in formation of endothelial dysfunction in patients with bronchial asthma
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p714
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p714.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p714.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - In the article we studied the role of CD38/ADP-ribosilcyclase in formation of endothelial dysfunction in patients with bronchial asthma.In the research we have been included patients with mild (1st group) and severe (2nd group) bronchial asthma. We found the increased expression of CD38 in peripheral blood lymphocytes in patients of both groups (in the 1st group 4 out of 300 cells, in the 2nd 6 out of 300 cells) in an exacerbation in comparison with the control group (2 out of 300 cells). Increase of level of expression CD38 promotes the realisation of the mechanism of interaction of the activated lymphocytes with the cells of endothelium expressing of non-substrated ligand CD38 – CD 31/sPECAM-1.We note increase of sPECAM-1 in plasma of peripheral blood in the 2nd group to 7,19 ng/ml [6,8; 7,7] in comparison with results of the patients of the 1st group: 6,78 ng/ml [6,09; 8,35] (p=0,022525). We found the positive interrelation between the level of CD31 and the expression of CD38 (r=0,3; p <0,05), and also direct correlation relationship between the level of CD31 and the concentration of C-reactive protein in blood plasma (r=0,39, p <0,01). The result of such relationship is the damage of cells of endothelium and formation of endothelial dysfunction which, in its turn, determines the disturbance of mechanisms of endothelial regulation of vascular wall elasticity and increase of its rigidity.