RT Journal Article
SR Electronic
T1 Influence of obesity on pulmonary function (PF) in severe asthmatic children
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p4263
VO 38
IS Suppl 55
A1 Verόnica Giubergia
A1 Verόnica Aguerre
A1 Silvia Caíno
A1 Hebe Gonzalez Pena
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p4263.abstract
AB While there have been reports in adults evaluating the effects of obesity on PF tests, in severe asthmatic children studies are scarce.Aim: To evaluate the influence of obesity on PF in children with asthma.Methods: 39 children (41% male) with controlled severe asthma with and without obesity, and 22 non asthmatic obese patients (59% male) were included. Patients were divided according to asthma diagnosis (NIH guidelines) and to Body Mass Index (BMI) cut off (IOTF): Group 1 asthma with normal weight, G2 asthma with obesity and G3 obesity without asthma. Spirometry and plethysmography were performed in all patients. Considered parameters were FVC, FEV1, FEV1/FVC, FMMF, TLC (total lung capacity), FRC (functional residual capacity), RV (residual volume) and sGaw (specific airway conductance). BMI corrected for age and sex and BMI z-score were assessed. PF between G1, 2 and 3 were compared. (ANOVA. Pearson correlation)Results: Mean age (SD), G1: 12 (3), G2: 12 (3), G3: 11.8 (3) (NS).View this table:Table 1. Pulmonary FunctionA significant inverse correlation between BMI z-score and FRC (r -0.5, p 0.001) and RV (r -0.4, p 0.006) was found between asthmatic patients.Conclusion: Obesity might influence PF decreasing FRC and RV despite of asthma diagnosis.