TY - JOUR T1 - Factors associated to an earlier wheezing episode during the first year of life in Europe and Latin America: The EISL study JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p1506 AU - Luis Garcia-Marcos AU - Javier Mallol AU - Dirceu Sole AU - Paul Brand AU - Manuel Sanchez-Solis AU - Virginia Perez-Fernandez Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p1506.abstract N2 - Background: There is scarce information about what factors might influence the time to the first wheezing episode in infants.Methods: The “Estudio Internacional de Sibilancias en Lactantes (EISL)” included 13,684 infants who wheezed at least once in the first year of life, recruited from 13 centres in 6 Latin American countries (n=12,045) and from 5 centres in 2 European countries (n=1,639). A multivariate Cox regression analysis was performed using as dependent variable the time to the first wheezing episode. The regression included the following factors: gender, parental asthma or rhinitis, infant eczema, mother smoking in pregnancy, cold(s) in the first 3 mo, nursery school, breast feeding >= 3 mo, number of siblings, persons at home, mould stains on walls, university studies of mother, Afro-American ethnicity, and pets at home. An adjusted hazard ratio (aHR) of the pooled whole population and also separately for EU and LA was calculated.Results:View this table:Adjusted hazard ratios (aHR) for an earlier episode of wheezing in the frist year of lifeConclusions: Some factors usually shown to be a risk factor for wheezing are not associated to a shorter period of time to the first episode. Furthermore, some delaying or advancing factors are different in Europe as compared to Latin America. ER -