TY - JOUR T1 - Acute effects of an aerobic exercise session on airway inflammation in a murine asthma model JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3910 AU - Ronaldo Aparecido da Silva AU - Rodolfo de Paula Vieira AU - Francine Maria de Almeida AU - Clarice Rosa Olivo AU - Beatriz Mangueira Saraiva AU - Milton Arruda Martins AU - Celso Ricardo Fernandes de Carvalho Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3910.abstract N2 - Background: Chronic effects of aerobic training (AT) seem to decrease inflammation in experimental asthma.Objective: Investigate the effects of a unique exercise session of aerobic exercise in a murine asthma model.Methods: Male Balb/c mice were divided in 4 groups: Control, AT, ovalbumin sensitized (OVA) and OVA+AT. OVA sensitization groups received i.p.(days 0,14,28) and OVA inhaled exposition (OVA1%, 3xweek/30min) after the 21st day. In the 28th day animals from AT and OVA+AT groups performed a session of treadmill running for 1 hour (50% maximal intensity). Evaluations: In vivo respiratory mechanic (Flexivent), different cell count in the BALF, and collagen fibers depositions and smooth muscle thickness in the airways were evaluated by an image analyzer.Results: Initial physical capacity was similar among groups (p>0.05). BALF total and inflammatory cells, collagen fiber and the smooth muscle thickness were increased in sensitized groups (p<0.05). Parameters of respiratory mechanic (Gtis and This) were also increased in groups sensitized groups (OVA and OVA+AT; p<0.05).Conclusions: Aerobic exercise when performed for acutely does not decrease features of experimental asthma such as cell migration, airway remodeling and respiratory mechanic. ER -