TY - JOUR T1 - The clinical significance of markers of endothelial dysfunction (ED) inprogression of idiopathic interstitial pneumonias (IIP) JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3881 AU - Andrew Ponomarev AU - Elena Popova AU - Marina Lebedeva AU - Sergei Bolevich AU - Vera Osypencko Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3881.abstract N2 - Angiogenesis and ED in IIP are considered as key mechanisms of remodeling in lung tissue and pulmonary hypertension (PH). TheAim of present study was to define some mediators of ED and angiogenesis (endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), Plasminogen Activator Inhibitor-1 (PAI-1) in patients with different clinical forms of IIP.Patients and methods: 39 patients (22 – usual interstitial pneumonia, 17 – nonspecific interstitial pneumonia) with morphologically proved IIP were investigated. Plasma concentrations of ET-1, VEGF and PAI-1 (ELISA) and morphometrics of lung biopsy for estimation of intensity of neoangiogenesis were performed.Results: Markes of ED positively correlated with HRCT patterns of lung fibrosis (VEGF r=0,31, p=0,004; ET-1 r=0,37 p=0,003, PAI-1 r=0,38, p=0,006 respectively) the level of VEGF in the blood correlated with parameters of neoangiogenesis in the lung tissue (r=0,37, p=0,001). Patients with PH in comparison with patients without PH demonstrated higher concentrations of ET-1 and PAI-1 (r=0,34, p=0,005 and r=0,37, p=0,002 respectively). Invert correlation was established between PAI-1 and DLCO (r = -0,71, p<0,05), PAI-1 and FVC (r = -0,72, p<0,05).Conclusion: These data demonstrate the important role of the studied markers of ED and neoangiogenesis in the mechanisms of IIP progression and may be used as predictors of survival. ER -