RT Journal Article
SR Electronic
T1 Impact of three back-up rate (BUR) on subjective quality of sleep (QoS) and residual events in obesity-hypoventilation (OHS) treated by home non invasive ventilation (NIV): A randomised controlled trial
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1436
VO 38
IS Suppl 55
A1 Olivier Contal
A1 Jean-Christian Borel
A1 Dan Adler
A1 Fabrice Espa
A1 Daniel Rodenstein
A1 Jean-Louis Pépin
A1 Jean-Paul Janssens
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/1436.abstract
AB Introduction: NIV is widely used to treat OHS. There is however no evidence in the literature for defining optimal BUR.Aim of study: To compare the impact of spontaneous ventilation (SV; BUR=0), low BUR (10.9±0.9/min) and high BUR (20.5±1.5/min) applied in random order during 3 consecutive nights in OHS patients. Main outcome: Sleep structure assessed PSG Secondary outcome: Hypoventilation and residual events.Methods: Polysomnography were scored for sleep structure, obstructive (OE), central (CE) and mixed (ME) respiratory events,% time spent with patient ventilator asynchrony (PVA) and nocturnal hypoventilation meaured by TcPCO2. Two questionnaires assessed subjective QoS.Results: Ten stable OHS patients under long term NIV (mean±SD; aged 55.7±9.2 yrs; BMI 48.5±5 kg/m2, PaCO2: 5.5±0.7 kPa) were included. Table 1 depicts main results.ODI, CE, ME and time spent with PVA were all much higher with SV than with either low or high BUR. Subjective QoS did not differ between SV and low BUR. However subjects with high BUR perceived more awakenings and a lower QoS than with low BUR whereas their Sleep efficiency was lower.Conclusion: In stable OHS patients under long term NIV, SV was associated with a very high rate of ODI, CE and ME when compared to low and high BUR. High BUR was perceived as less comfortable than low BUR.